Principal Scientist, Rare Variant Modeling
Company: Disability Solutions
Location: Cambridge
Posted on: May 3, 2024
Job Description:
Working with UsChallenging. Meaningful. Life-changing. Those
aren't words that are usually associated with a job. But working at
Bristol Myers Squibb is anything but usual. Here, uniquely
interesting work happens every day, in every department. From
optimizing a production line to the latest breakthroughs in cell
therapy, this is work that transforms the lives of patients, and
the careers of those who do it. You'll get the chance to grow and
thrive through opportunities uncommon in scale and scope, alongside
high-achieving teams rich in diversity. Take your career farther
than you thought possible.Bristol Myers Squibb recognizes the
importance of balance and flexibility in our work environment. We
offer a wide variety of competitive benefits, services and programs
that provide our employees with the resources to pursue their
goals, both at work and in their personal lives. Read more:
careers.bms.com/working-with-us .When you join BMS, you are joining
a diverse, high-achieving team united by a common mission. The
Informatics and Predictive Sciences (IPS) mission is to Pioneer,
Partner and Predict to drive transformative insights for patient
benefit. IPS conducts applied computational research in areas that
include genomic, structural and molecular informatics,
computational and systems biology, patient selection and
translational biomarker research, and broader fields including
knowledge science, epidemiology and machine learning-across the
full lifecycle of drug discovery and development and across all
therapeutic areas at BMS. We do this in close partnership with
scientific and clinical experts in the field, both inside and
outside the company." We perform innovative science to empower key
data-driven decisions across a rich pipeline of next-generation
medicines. In doing so, our work transforms the lives of patients,
as well as our own lives and careers.Here, you'll get the chance to
grow and thrive through opportunities that are uncommon in scale
and scope. You'll pursue innovative ideas while advancing
professionally alongside some of the brightest minds in
biopharma.We seek a talented computational researcher and leader to
use large genetic biobank datasets to define genetics dose response
for novel target mechanisms ahead of future clinical trials. This
role will sit within Informatics & Predictive Sciences, a globally
distributed group driving innovative computational research for
discovery and early development within BMS research.A key focus
will be the development and application of novel rare variant
methods that combine results from large-scale DNA sequencing data
sets with experimental perturbation within in vitro cellular
models, ultimately to infer the mechanistic effects of
disease-associated variants. Using methods that combine across
allelic series, this work will provide a genetics-based estimate of
the quantitative relationship between target pathway function and
efficacy/safety outcomes, well ahead of clinical trials.This
position offers an exciting opportunity to impact human health
through innovative human genomics research, and it will enable
discovery groups within BMS research to launch novel programs based
on causal human biology. It is also an opportunity to work closely
with the broader scientific community through pre-competitive
collaborations (e.g. FinnGen, UK Biobank, UK Genes & Health,
Alliance for Genomic Discovery), and to publish and present
industry-leading work in this area. Location: Cambridge,
MAResponsibilities will include, but are not limited to, the
following:
- Provide scientific leadership, strategic oversight, and
technical guidance on efforts to build and integrate across a suite
of genetic biobank data resources to empower future genetic dose
response modeling
- Perform cross-biobank analyses focused on rare-variant and
burden association tests
- Develop and/or implement methods to infer the quantitative
relationship between variant function and clinical phenotypes
across allelic series
- Use population genetic models to inform the design of future
genetic biobank studies
- Work as part of cross-functional teams in efforts to use
saturation mutagenesis and other experimental methods to define
functional effects of genetic variants
- Mentor team members through leadership of matrix teams
- Communicate findings and recommend follow up actions in
multiple settings (including 1:1, seminars, project meetings, and
external publications)Basic Qualifications:
- Bachelor's Degree in population or statistical genetics, or a
related computational/quantitative discipline field and 8+ years of
academic / industry experience
- or Master's Degree in population or statistical genetics, or a
related computational/quantitative discipline field and 6+ years of
academic / industry experience
- or PhD in population or statistical genetics, or a related
computational/quantitative discipline field and 4+ years of
academic / industry experiencePreferred Qualifications:
- PhD in population or statistical genetics, or a related
computational/quantitative discipline field
- 4 or more years relevant industry experience, preferred
- 2+ years of leadership experience
- Deep scientific expertise in population genetic models and
analyses of rare variants (e.g. long-standing working experience in
this area and/or a track record of high-impact peer-reviewed
publications)
- Experience applying genetics to drug discovery or other
healthcare-related applications
- Advanced hands-on knowledge of at least one high-level
programming language such as R or Python
- Familiarity with functional genomics and genetic perturbation
technologies preferred
- Demonstrated ability to advance multi-disciplinary team
projects required; mentorship experience preferred If you come
across a role that intrigues you but doesn't perfectly line up with
your resume, we encourage you to apply anyway. You could be one
step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing CareersWith a single
vision as inspiring as Transforming patients' lives through
science--- , every BMS employee plays an integral role in work that
goes far beyond ordinary. Each of us is empowered to apply our
individual talents and unique perspectives in an inclusive culture,
promoting diversity in clinical trials, while our shared values of
passion, innovation, urgency, accountability, inclusion and
integrity bring out the highest potential of each of our
colleagues.On-site Protocol BMS has a diverse occupancy structure
that determines where an employee is required to conduct their
work. This structure includes site-essential, site-by-design,
field-based and remote-by-design jobs. The occupancy type that you
are assigned is determined by the nature and responsibilities of
your role: Site-essential roles require 100% of shifts onsite at
your assigned facility. Site-by-design roles may be eligible for a
hybrid work model with at least 50% onsite at your assigned
facility. For these roles, onsite presence is considered an
essential job function and is critical to collaboration,
innovation, productivity, and a positive Company culture. For
field-based and remote-by-design roles the ability to physically
travel to visit customers, patients or business partners and to
attend meetings on behalf of BMS as directed is an essential job
function. BMS is dedicated to ensuring that people with
disabilities can excel through a transparent recruitment process,
reasonable workplace accommodations/adjustments and ongoing support
in their roles. Applicants can request a reasonable workplace
accommodation/adjustment prior to accepting a job offer. If you
require reasonable accommodations/adjustments in completing this
application, or in any part of the recruitment process, direct your
inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/
eeo -accessibility to access our complete Equal Employment
Opportunity statement. BMS cares about your well-being and the
well-being of our staff, customers, patients, and communities. As a
result, the Company strongly recommends that all employees be fully
vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest
and conviction records, pursuant to applicable laws in your
area.Any data processed in connection with role applications will
be treated in accordance with applicable data privacy policies and
regulations.
Keywords: Disability Solutions, Waltham , Principal Scientist, Rare Variant Modeling, Other , Cambridge, Massachusetts
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