Senior Staff Engineer, Modeling
Company: Takeda
Location: Boston
Posted on: July 8, 2025
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Job Description:
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information I provide in my application will be processed in line
with Takeda’s Privacy Notice and Terms of Use . I further attest
that all information I submit in my employment application is true
to the best of my knowledge. Job Description About the role: At
Takeda, we are a forward-looking, world-class R&D organization
that unlocks innovation and delivers transformative therapies to
patients. By focusing R&D efforts on four therapeutic areas and
other targeted investments, we push the boundaries of what is
possible in order to bring life-changing therapies to patients
worldwide. Synthetic Molecule Process Development (SMPD) develops
robust and cost-effective processes for the manufacture of new
small molecule pharmaceuticals, along with methods for achieving
and controlling high standards of purity and quality. The Senior
Staff Engineer – Process Modeling will join a dynamic and
innovative team of engineers and scientists within SMPD’s Process
Engineering & Technology Group. Join Takeda as a Senior Staff
Engineer – Modelingwhere you will have a strong background in
chemical reaction engineering and will tackle and lead challenging
problems in chemical reactions by leveraging expertise in reaction
kinetics, transport phenomena, mathematical modeling, and reactor
design. You will also lead and develop the scale-up and scale-down
models for studying unit operations using both first-principle and
data-based models. The role includes the application of process
analytical technologies (PAT) combined with mathematical models
(both statistical and first principle) to enhance process
understanding. This will enable the effective development,
optimization, scale-up, and troubleshooting of processes using
in-silico approaches. As part of the SMPD, you will report to
Associate Engineering Fellow. How you will contribute: Lead and
contribute to the design, development, optimization, and scale-up
of manufacturing processes for synthetic molecule drug substances
using process modeling and simulation principles. Utilize advanced
process modeling tools and digital twin functionalities,
implementing model-based design of experiments for process
characterization and risk assessment. Lead and develop experimental
designs and workflows for model development, validation, and
verification. Collaborates with cross-functional and external
partners to develop and deploy digital twins of unit operations.
Partner with Automation, Manufacturing, Process Engineers, and PAT
experts to develop modeling and simulation (M&S) solutions that
can be deployed across the global organization for in-silico
process design, development, and optimization. Recommend, justify
and implement in silico tools and an " in-silico first” approach to
process development. Contribute to the democratization of modeling
and simulation tools & results within global SMPD. Develop project
or significant technical strategy and leverages technical skill(s)
as a resource/expert within the department. Recognized as a
technical expert and resource within the function Contribute
significantly and independently to project work as well as the
development of platforms, which may include multiple projects
within functional area. Proactively analyze technical issues and
coordinate potential resolutions with project team members based on
model and simulation predictions. Review, interpret and communicate
data cross functionally within pharmaceutical sciences and project
teams. Significant technical responsibility for a project
area/technical program within the department and potentially across
Pharmaceutical sciences. Stay current in novel process modeling and
simulation tools and platforms, identify process trends and
defines/champions process strategy. Influence and support
initiatives related to driving scientific and technical improvement
within the function and potentially cross-functionally. Identify
topics for initiatives and lead local/global initiatives on behalf
of senior staff. Author relevant sections of regulatory documents,
validation plans, reports and peer reviewed manuscripts. Identify
vendors and build relationships to gain access to technologies as
needed to deliver on pipeline and platform technology goals. Manage
key vendor relationships across multiple projects as appropriate,
and proactively affects resolution of issues arising at vendors.
Represent Takeda and is an active member on pre-competitive
collaborations with academic and industrial partners. Minimum
Requirements/Qualifications: Required: Bachelor's degree in
Chemical Engineering or a related pharmaceutical science with 11
years of relevant industry experience. Master's degree in Chemical
Engineering or a related pharmaceutical science with 9 years of
relevant industry experience. Ph.D. or postdoctoral fellowship in
Chemical Engineering or a related pharmaceutical science with 3
years of relevant industry experience. Strong knowledge and
understanding of chemical reaction engineering and catalysis, with
proven ability to demonstrate skills in these fields. Strong
knowledge and understanding of transport phenomena and
thermodynamics. Extended experience with commercially available
reaction kinetic modeling software such as Ansys, ReactionLab,
Dynochem, and gPROMS. Extended experience with commercially
available software for computational fluid dynamics (CFD) modeling
such as Ansys, Star CCM, MStar CFD. Proficient in communicating and
data collection from systems such as sensors, controllers, and
industrial systems. Experience with Matlab, Python, R, SQL, and
good coding practices. Preferred: Experience with common
statistical methods, basic data science principles, and AI/ML
methodologies. Hands-on experience in wet lab process development.
Experience in multivariate analysis and Principal Component
Analysis (PCA). Understanding of synthetic molecule process
development activities. Understanding of current Good Manufacturing
Practices (cGMP) Knowledge and Skills: Analytical and Problem
Solving Skills - Able to troubleshoot critical issues or problems,
and determine causes and possible solutions. Teamwork Ability to
work well in highly cross functional team environment and across
global line functions. Communication Skills -Able to expresses
one’s self clearly and concisely within team; documents issues
and/or concerns concisely with colleagues; adjust communication
style as appropriate for the audience; timely and effectively
communicates issues to supervisor; technical writing skills to
support authorship of internal technical documents. Organization –
Exercises good time management and prioritization skills and is
able to successfully manage multiple tasks simultaneously.
Knowledge Sharing - Ability to capture organizational knowledge;
improve solutions, processes, and deliverables through use of
information; improve information capital by contributing
experience, theories, deliverables, and models for others to use.
Resource Management - Ability to manage one’s time within
individual, departmental, and corporate goals and timelines;
management of internal and external resources (vendors). External
Involvement – Demonstrated involvement in professional community
evidenced by presentation of scientific posters or lectures at
professional conferences or events. Technical- Subject matter
expertise and knowledge of applicable process modeling and
simulation tools. Travel Requirements: May require approximately
5-10% travel. More about us: At Takeda, we are transforming patient
care through the development of novel specialty pharmaceuticals and
best in class patient support programs. Takeda is a patient-focused
company that will inspire and empower you to grow through
life-changing work. Certified as a Global Top Employer, Takeda
offers stimulating careers, encourages innovation, and strives for
excellence in everything we do. We foster an inclusive,
collaborative workplace, in which our teams are united by an
unwavering commitment to deliver Better Health and a Brighter
Future to people around the world. Takeda Compensation and Benefits
Summary We understand compensation is an important factor as you
consider the next step in your career. We are committed to
equitable pay for all employees, and we strive to be more
transparent with our pay practices. For Location: Boston, MA U.S.
Base Salary Range: $137,000.00 - $215,270.00 The estimated salary
range reflects an anticipated range for this position. The actual
base salary offered may depend on a variety of factors, including
the qualifications of the individual applicant for the position,
years of relevant experience, specific and unique skills, level of
education attained, certifications or other professional licenses
held, and the location in which the applicant lives and/or from
which they will be performing the job.The actual base salary
offered will be in accordance with state or local minimum wage
requirements for the job location. U.S. based employees may be
eligible for short-term and/or long-termincentives. U.S.based
employees may be eligible to participate in medical, dental, vision
insurance, a 401(k) plan and company match, short-term and
long-term disability coverage, basic life insurance, a tuition
reimbursement program, paid volunteer time off, company holidays,
and well-being benefits, among others. U.S.based employees are also
eligible to receive, per calendar year, up to 80 hours of sick
time, and new hires are eligible to accrue up to 120 hours of paid
vacation. EEO Statement Takeda is proud in its commitment to
creating a diverse workforce and providing equal employment
opportunities to all employees and applicants for employment
without regard to race, color, religion, sex, sexual orientation,
gender identity, gender expression, parental status, national
origin, age, disability, citizenship status, genetic information or
characteristics, marital status, status as a Vietnam era veteran,
special disabled veteran, or other protected veteran in accordance
with applicable federal, state and local laws, and any other
characteristic protected by law. Locations Boston, MA Worker Type
Employee Worker Sub-Type Regular Time Type Full time Job Exempt Yes
It is unlawful in Massachusetts to require or administer a lie
detector test as a condition of employment or continued employment.
An employer who violates this law shall be subject to criminal
penalties and civil liability.
Keywords: Takeda, Waltham , Senior Staff Engineer, Modeling, Engineering , Boston, Massachusetts
