Associate Director, PK Sciences
Company: Novartis Group Companies
Location: Cambridge
Posted on: April 24, 2024
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Job Description:
393240BR
Associate Director, PK Sciences
USA
About the role
About the role:
Position will be on-site in Cambridge, MA and will not have the
ability to be located remotely.
In the role of Associate Director in PK Sciences you will provide
ADME /PK/PKPD project support to the Neuroscience Therapeutic Area
contributing to projects from Discovery to IND filing and
First-in-Human studies and beyond. In this unique role you will
collaborate and partner with PK Sciences functions including in
vitro and in vivo ADME, biotransformation, bioanalytics and
modeling & simulation and represent the PK Sciences organization
within project teams.
Your Key Responsibilities:
- Support teams in developing the strategy for, and coordinate the
implementation of, the characterization and selection of lead
compounds and drug candidates with favorable PK/ADME properties,
elucidate PK/PD relationships driving efficacy/safety and
contribute to human PK prediction and dose and regimen
selection.
- Provide matrixed leadership across the organization to align and
influence across the cross-functional team to identify and mitigate
key project issues related to the pharmacokinetic sciences [PKS]
discipline (PK, PK/PD, metabolism and clinical pharmacology).
- Proactively contribute to develop candidate drug products from
early discovery and beyond, providing expert pharmacokinetic / drug
metabolism and clinical pharmacology input.
- Be responsible for the PK, PK/PD and M&S component of study
protocols, reports, project summaries and development plans, and
author pharmacokinetic/clinical pharmacology/biopharmaceutics
sections of IND/IMPDs within agreed timelines and which meet
regulatory requirements as well as prepare appropriate responses to
Health Authority questions (globally).
- Oversee or perform PK and PK/PD analyses using a variety of tools
and approaches and integrate, interpret and report data to project
teams and other customers. Our organization further offers the
opportunity to seamlessly gain exposure to different stages of
development, different drug modalities and cross-train in multiple
indications.
EEO Statement
We are Equal Opportunity Employers and take pride in maintaining a
diverse environment. We do not discriminate in recruitment, hiring,
training, promotion or other employment practices for reasons of
race, color, religion, gender, national origin, age, sexual
orientation, gender identity or expression, marital or veteran
status, disability, or any other legally protected status. We are
committed to building diverse teams, representative of the patients
and communities we serve, and we strive to create an inclusive
workplace that cultivates bold innovation through collaboration and
empowers our people to unleash their full potential.
Accessibility and Reasonable Accommodations: Individuals in need of
a reasonable accommodation due to a medical condition or disability
for any part of the application process, or to perform the
essential functions of a position, please let us know the nature of
your request, your contact information and the job requisition
number in your message:
Role Requirements
Essential Requirements:
* Ph.D. / Pharm.D. with relevant experience in clinical
pharmacology, drug metabolism and pharmacokinetics or a related
biologic background.
* A minimum of 6 plus years in a drug discovery/early development
function including 2 plus years of experience in a lead role
overseeing ADME/DMPK strategy of compound development.
* Extensive and in-depth knowledge of pharmacokinetics including,
drug metabolism and PK/PD evaluation, experience in working in
project teams (preferably global) as well as sound awareness of
recent developments in drug development and regulatory
sciences.
* Proficient in the application of PK and PK/PD analysis with
working knowledge of software such as WINNONLIN/Phoenix
* Hands-on project experience with low molecular weight drug
discovery and development.
* Proven record as leader with good negotiation, organizational and
project management skills.
* Strong coaching and mentoring skills desired.
Why Novartis: Our purpose is to reimagine medicine to improve and
extend people's lives and our vision is to become the most valued
and trusted medicines company in the world. How can we achieve
this? With our people. It is our associates that drive us each day
to reach our ambitions. Be a part of this mission and join us!
Learn more here:
https://www.novartis.com/about/strategy/people-and-culture
You'll receive:
You can find everything you need to know about our benefits and
rewards in the Novartis Life Handbook.
https://www.novartis.com/careers/benefits-rewards
Commitment to Diversity & Inclusion: Novartis is committed to
building an outstanding, inclusive work environment and diverse
teams' representative of the patients and communities we serve.
Accessibility and Reasonable Accommodations: The Novartis Group of
Companies are committed to working with and providing reasonable
accommodation to individuals with disabilities. If, because of a
medical condition or disability, you need a reasonable
accommodation for any part of the application process, or in order
to perform the essential functions of a position, please send an
e-mail to tas.nacomms@novartis.com call +1(877)395-2339 and let us
know the nature of your request and your contact information.
Please include the job requisition number in your message.
Novartis Compensation and Benefit Summary: The pay range for this
position at commencement of employment is expected to be between
$151,200 - $226,800/year; however, while salary ranges are
effective from 1/1/24 through 12/31/24, fluctuations in the job
market may necessitate adjustments to pay ranges during this
period. Further, final pay determinations will depend on various
factors, including, but not limited to geographical location,
experience level, knowledge, skills, and abilities. The total
compensation package for this position may also include other
elements, including a sign-on bonus, restricted stock units, and
discretionary awards in addition to a full range of medical,
financial, and/or other benefits (including 401(k) eligibility and
various paid time off benefits, such as vacation, sick time, and
parental leave), dependent on the position offered. Details of
participation in these benefit plans will be provided if an
employee receives an offer of employment. If hired, employee will
be in an "at-will position" and the Company reserves the right to
modify base salary (as well as any other discretionary payment or
compensation program) at any time, including for reasons related to
individual performance, Company or individual department/team
performance, and market factors.
Join our Novartis Network: If this role is not suitable to your
experience or career goals but you wish to stay connected to learn
more about Novartis and our career opportunities, join the Novartis
Network here: https://talentnetwork.novartis.com/network
Division
Biomedical Research
Business Unit
Translational Medicine
Work Location
Cambridge, MA
Company/Legal Entity
NIBRI
Functional Area
Research & Development
Job Type
Full Time
Employment Type
Regular
Shift Work
No
Early Talent
No
Keywords: Novartis Group Companies, Waltham , Associate Director, PK Sciences, Executive , Cambridge, Massachusetts
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