Manager, HR Operations & Onboarding

Company: Dyne Therapeutics
Location: Waltham
Posted on: December 1, 2025

Job Description:

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more https://www.dyne-tx.com/ , and follow us on X , LinkedIn and Facebook . Role Summary: The Manager, HR Operations & Onboarding will partner with the HR team to continuously enhance Dyne’s core HR operational functions, including onboarding, HRIS administration, benefits coordination, and process optimization. This role will ensure a seamless and engaging experience for new hires, maintain data integrity across Dyne’s HR systems (ADP Workforce Now and Greenhouse ATS), and drive automation to enable scalability, efficiency, and a best-in-class employee experience. This role is based in Waltham, MA without the possibility of being remote. Key Responsibilities Support day-to-day HR operations, ensuring accuracy, efficiency, and compliance across onboarding, HRIS management, and benefits administration Oversee and optimize workflows within ADP Workforce Now and Greenhouse ATS, ensuring seamless data flow and system integration Design, manage, and continuously improve Dyne’s onboarding processes, systems, and programs to deliver an engaging and consistent new hire experience aligned with Dyne’s culture and values Serve as the first point of contact for general HR inquiries, providing timely and accurate support to employees and managers Ensure compliance with all employment-related documentation and recordkeeping requirements Collaborate closely with Talent Acquisition, IT, and HR Business Partners to streamline processes and enhance service delivery Partner with external vendors to manage Service Level Agreements and ensure high-quality service delivery Oversee contract lifecycle and purchase order management, including creation, tracking, and reconciliation, ensuring alignment with procurement policies and timely vendor invoicing and payment processing Identify, recommend, and implement automation or process improvements that enhance operational efficiency and employee experience Support HR policy development, ensuring alignment with Dyne’s culture and compliance with applicable laws and regulations Generate, analyze, and maintain accurate HR reports and dashboards by extracting data from HRIS and other systems to support strategic decision-making, compliance, and operational efficiency Own the data submission of compensation benchmarking reports Assist with immigration-related requests, documentation, and processes Assist with benefits administration Education and Skills Requirements: Bachelor’s degree in Human Resources, Business Administration, or a related field 5 years of HR operations experience, preferably within biotech, pharmaceutical, or high-growth life sciences environments Hands-on experience with ADP Workforce Now and Greenhouse ATS preferred Experience designing and managing onboarding programs that provide a seamless introduction to Dyne’s culture and mission Strong analytical and problem-solving skills with attention to detail and data accuracy Excellent communication and organizational skills, with the ability to manage multiple priorities Demonstrated curiosity, continuous improvement mindset, and ability to drive process innovation Sense of urgency and intrinsic motivation to drive projects, generate solutions/ideas, and build knowledge and expertise LI-Onsite MA Pay Range $118,340 - $145,500 USD The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Keywords: Dyne Therapeutics, Waltham , Manager, HR Operations & Onboarding, Human Resources , Waltham, Massachusetts