Principal Scientist, Protein Engineering and Platform Development

Company: Stratacuity: Proven Scientific Placement
Location: Waltham
Posted on: September 12, 2020

Job Description:

Principal Scientist, Protein Engineering and Platform Development Waltham, MA

Principal Scientist, Protein Engineering and Platform Development 1086648

Job Scope & Purpose:

This is an exciting opportunity for a creative, talented and highly motivated scientist to join the newly formed Platform Innovation group. The successful candidate will join a dynamic intercontinental team responsible for developing novel technologies to identify and optimize protein therapeutics, and will interface with diverse therapeutic functions across immune-oncology, autoimmune, infectious diseases, and neuroscience. The candidate is expected to be up to date on advanced technologies for protein engineering and drug delivery, including localized intertumoral delivery and delivery across blood-brain barrier (BBB) and actively bring in new concepts to continuously improve functional area capabilities and innovations. A track record of scientific creativity and accomplishments as evidenced by a strong publication record, patents and pipeline contributions is expected.

Primary Job Responsibilities:

Provide expertise in cutting edge protein engineering techniques, protein structure analysis, bio molecular modeling, protein structure prediction and computational drug design

Contribute to the design and testing of novel engineering strategies for BBB penetration

Work closely with immuno-neurology team to identify therapeutic biologic candidates with enhanced ability to cross BBB and other methods to optimize brain exposure of biologic therapeutic candidates

Use structure-based approach to engineer unique molecules to achieve desired biological activity, stability and pharmacokinetic properties

Perform antibody humanization, sequence and in-silico affinity optimization

Collaborate with our computational biology group to develop deep learning methods for prediction of developability properties on monoclonal antibodies

Work closely and interface collaboratively with other groups in a multidisciplinary company at both sites

Author technical reports, patent applications, IND reports and scientific publications

Primary Job Requirements:

Ph.D. degree in biophysics, biochemistry, structural biology, chemical engineering, or related discipline

5-8+ years of industry experience in protein therapeutics drug discovery and development with a track record of biologics pipeline contributions

Demonstrated hands-on expertise in bi-specific and multi-specific, Fc-fusion proteins engineering and optimization, knowledge of different bi specific formats and strong understanding of structure-function relationship

Extensive theoretical knowledge and practical experience with different techniques of large-molecule therapeutics delivery into the brain and ways to optimize brain exposure of biologic therapeutic candidates

Demonstrated experience in humanization of mAbs obtained from different species, antibody sequence optimization and designing antibodies with excellent biophysical and manufacturing properties

Deep understanding of protein biochemistry and state of the art methods of protein characterization

Understanding of patent landscape in the antibody space is a plus

Strong results-driven “can-do” personality with a high level of enthusiasm, energy, and confidence

Excellent communication, time management, and organization skills

Track record of scientific accomplishments as evidenced by a strong publication record, patents and pipeline contribution

About Stratacuity:

Whether you are seeking a career change or simply interested in becoming part of our network, you will appreciate the ethics guiding each Stratacuity team member. We build lasting relationships with exceptional biopharmaceutical talent and take great care to protect your personal information. Upon receiving your inquiry, you may be directly contacted by a Stratacuity team member to discuss your career goals. We will not share your information with anyone without your direct prior consent.

Stratacuity is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stratacuity will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact us.

Apex Systems is an equal opportunity employer. We do not discriminate or allow discrimination on the basis of race, color, religion, creed, sex (including pregnancy, childbirth, breastfeeding, or related medical conditions), age, sexual orientation, gender identity, national origin, ancestry, citizenship, genetic information, registered domestic partner status, marital status, disability, status as a crime victim, protected veteran status, political affiliation, union membership, or any other characteristic protected by law. Apex will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact our Employee Services Department at employeeservices@apexsystemsinc.com or 844-463-6178.

Apex Systems dba Stratacuity, is an equal opportunity employer. We do not discriminate or allow discrimination on the basis of race, color, religion, creed, sex (including pregnancy, childbirth, breastfeeding, or related medical conditions), age, sexual orientation, gender identity, national origin, ancestry, citizenship, genetic information, registered domestic partner status, marital status, disability, status as a crime victim, protected veteran status, political affiliation, union membership, or any other characteristic protected by law. Stratacuity will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law.

Keywords: Stratacuity: Proven Scientific Placement, Waltham , Principal Scientist, Protein Engineering and Platform Development, Other , Waltham, Massachusetts