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(Associate) Director, DMPK

Company: xili? Therapeutics, Inc.
Location: Waltham
Posted on: September 12, 2020

Job Description:

Xilio Therapeutics is a development-stage biotechnology company advancing next-generation cancer immunotherapies designed to improve patient outcomes by unleashing the power of the immune system selectively at the site of the tumor. The company’s tumor-selective immunotherapies are based on its proprietary technology, which maximizes the potency of proven immuno-oncology therapies and restricts their activity to the tumor to minimize peripheral side effects. The broad applicability of these therapies across cancer types means that all patients could benefit from these potentially curative medicines.

Xilio was founded in 2016, and closed a $100.5M Series B financing from blue chip venture investors in February 2020. Xilio is headquartered in Waltham, MA.

SUMMARY:

We are looking for a highly energetic and motivated (Associate) Director to lead our DMPK efforts. This person will be responsible for detailed discovery and non-clinical DMPK characterization of novel biologics based tumor selective immunotherapies. The successful candidate will have wide-ranging responsibilities within research and development focused project teams and the opportunity to work within a highly collaborative, dynamic, and interdisciplinary team.

The position will be based in Waltham, Massachusetts, and reports to the Vice President, Pharmacology

Responsibilities

Provide bioanalytical and assay expertise to enable pre-clinical pharmacologic assessments of novel biologics-based tumor selective immunotherapies

Collaborate effectively with the research team to develop and execute pre-clinical assays and validate those for use in non-clinical and clinical studies, including assays to assess PK, ADA and neutralizing antibodies

Develop interdisciplinary collaborations and ensure DMPK analyses, studies and priorities are integrated into overall project team strategy.

Work with external collaborators and service providers to support key project goals including quantitative systems pharmacology modeling to inform non-clinical and clinical studies

Responsible for the design and interpretation of DMPK assays, studies and technical report writing necessary for the selection of clinical candidates and for the filing of regulatory documents.

Qualifications

Candidate should have a Ph.D. or equivalent in a relevant scientific discipline, pharmacology or pharmaceutical sciences with 8+ years of experience in DMPK roles

Experience with discovery and development of novel biologics therapies, including reagent generation, and assay development to support PK studies, and assessment of ADA and neutralizing antibodies

Experience with writing of technical reports in support of regulatory filings

Strong understanding of guidance from regulatory agencies on DMPK assay development and qualification

Excellent communication skill with ability to function within cross functional teams.

Ability to independently design experiments, analyze experimental data and present results in both non-clinical and clinical development team settings.

Goal oriented, organized, capable of prioritizing and working on multiple projects, and able to execute to timelines that meet company goals

Excellent verbal and written communication skills

Driven by a desire to create the next generation of immunotherapy-based cancer therapeutics and the vision to offer cancer patients efficacious and tolerable new therapies that extend and improve their lives.

Xilio offers the opportunity to work in an innovation driven, exciting biotechnology company doing ground-breaking work in the field of immuno-oncology. We offer a competitive compensation package including a base salary, annual bonus potential, stock options, 401k, healthcare benefits and paid time-off.

POSITION: Full-Time, Exempt

EEOC Statement: Xilio Therapeutics believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Xilio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Are you Authorized to work lawfully in the United States  *

Will you now or in the future require Xilio to commence (“sponsor”) an immigration case in order to employ you (for example, H-1B or other employment-based immigration case)?  *

Keywords: xili? Therapeutics, Inc., Waltham , (Associate) Director, DMPK, Other , Waltham, Massachusetts

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