Senior Scientist Chemistry - CB- Chemical Biology
AstraZeneca is a global, science-driven biopharmaceutical
company. We are dedicated to discovering, developing, and
delivering innovative, meaningful medicines and healthcare
solutions that enrich the lives of patients. In AstraZeneca
Oncology, our goal is to be at the forefront of developing the next
generation of cancer therapies.
Team player responsible for the design, synthesis and strategies
around chemical tools/probes and their application towards target
ID, target engagement, and mechanism of action studies. An ideal
candidate will have hands-on experience in quantitative proteomics
experiments and/or experiences in biological target validation
The Senior Scientist Chemistry CB will be accountable for
specified aspects of the chemical biology strategies according to
the project objectives that include:
Designing and delivering on time to projects with the highest
scientific standards, utilizing proteomics-based methods such as
chemoproteomics pull-downs, photocrosslinking and global proteomics
to address specific biological questions.
Collaborating with the chemical biology proteomics platform for
technical design and with quantitative biology for statistical
analysis and downstream pathway analysis.
Setting and maintaining the highest scientific standards in
design and synthesis of small molecules.
Embedded into drug discovery project teams, demonstrating
effective engagement with other disciplines (e.g. chemistry,
Actively contribute and advance the scientific direction of
projects as a member of cross-functional teams through regular
attendance of project team meetings, presentation of their data and
contribute to the overall success of the project.
Contribute to publication strategy as needed, driving timely
preparation and delivery of patents/research publications in
collaboration with IP group.
To evaluate and manage relations with external collaborations
when and as needed.
Leading local discovery working groups, participate actively in
global groups or global activities.
Scope and internalize new methods for target identification and
Ensure compliance with corporate policies including GLS and
Will require a minimum: PhD in chemical biology or chemistry
with postdoctoral experience (0-3+ yrs.) in chemical biology, or
similar disciplines. Will have the ability to operate effectively
in multidisciplinary matrix research environment, providing
leadership and insight in their discipline. This role demands
significant experience of interacting with people and groups both
internal and external.
The ideal candidate should:
Be familiar with chemical biology principles and technologies,
and their application to small molecule target identification,
engagement and validation.
Independently design and execute target identification and
validation experiments for cellular signaling pathway
interrogation, hypothesis testing and practical knowledge with
suitable biological models and positive and negative small molecule
Should be versed in numerous small molecule bio-orthogonal
conjugation approaches applicable to in-lysate and live cell
chemical pull-down experiments.
Familiarity with bottom-up mass spectrometry-based applications
for in cell and in-vitro quantitative proteomics.
Preferably have an understanding of cell biology and
biochemistry techniques, such as cell lysing, protein extraction
Be active in Chemical Biology forums and publication record in
the field (communications to symposiums, peer reviewed journal
articles and/or patent applications).
Areas of expertise/specialization
Experience and track record in chemical biology and synthetic
Awareness of recent development in literature in the field of
chemical biology as well as synthetic & medicinal chemistry both
inside and outside AstraZeneca.
Good communication and networking skills.
Next Steps Apply today!
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