Associate Director, Translational PKPD Modeling & DMPK
AstraZeneca is a global biopharmaceutical company driven by what
science can do. We are dedicated to discovering, developing, and
delivering innovative, meaningful medicines and healthcare
solutions that enrich the lives of patients. The vision of
AstraZeneca Oncology is to redefine cancer, redefine our solutions
to cancer, and restore patients' lives. To achieve this, we have an
exciting and diverse portfolio that focuses on four scientific
platforms that we believe show the greatest potential for yielding
effective medicines for cancer patients. These scientific platforms
include; Immuno-Oncology (IO), Tumor Drivers & Resistance (TDR),
DNA Damage Response (DDR) and Antibody Drug Conjugates (ADC) and we
are developing therapeutic agents across multiple modalities
including; small molecules, biologics, Antibody Drug Conjugates
(ADCs), nano-medicines and PROTACs.
The Oncology DMPK department provides drug metabolism &
pharmacokinetic, as well as Translational PKPD Modelling &
Simulation support to our portfolio. Translational PKPD Modelling &
Simulation scientists occupy high profile, visible roles within
Early Oncology. We are looking for a senior individual who has a
passion for PKPD modelling and DMPK science, applied to Cancer
biology, with the experience of working in both discovery and
As a senior Translational PKPD Modelling & Simulation scientist,
you will have the opportunity to drive strategy and provide global
leadership in PKPD science across our diverse portfolio. Your
day-to-day role is to provide projects with expert modelling input
into exploring the PK/PD/Efficacy in pre-clinical models, and using
these models in order to iteratively build an understanding of the
dose & schedule requirements for therapeutic intervention across
different patient populations as a single agent and combined with
The role holder will contribute to DMPK Modelling and Simulation
Representing Oncology DMPK and providing overall scientific
leadership for cross functional and external collaborations
Exploring the effects on target and pathway to understand the
requirements for efficacy and set a candidate drug target profile
Predicting human dose and regimen together with providing input
into exposure and pharmacodynamic (PD) biomarker based decision
criteria for early clinical trials.
Driving learning through back translation of early clinical
exposure and PD data and providing prioritized future options for
Leading and participating in Oncology strategic scientific
initiatives and continuous improvement projects by providing expert
Having a breadth of influence and impact across AstraZeneca DMPK
and externally within their discipline.
Identifying, championing and developing new ideas.
Leading scientific discipline networks and acting as a focus for
debate within the AstraZeneca scientific community.
Advising on and participating in the development of Discovery or
Development strategies in PKPD for biologics/ADCs/small
Managing student and Post Doc programmes.
Leading external collaborative projects with academic or
cross-pharma pre-competitive groups.
Providing disciplinary scientific leadership and presenting work
through patents, publications and lectures.
PhD or equivalent degree in a discipline with a significant
component of Modelling & Simulation, such as systems biology,
quantitative pharmacology, pharmacometrics, chemical engineering,
physics, pharmaceutical sciences or applied mathematics.
At least 5 years of relevant industry experience in Modelling &
Simulation, ideally in preclinical/translational setting, or a MS
degree with at least 10 years of relevant industry experience.
Experience in a project-facing role at pharmaceutical
Comprehensive understanding of DMPK and pharmacology/safety
aspects of drug discovery and development.
Track record of supporting PK, PKPD and TKPD aspects of
projects, with a delivery focus and ability to meet timelines to
pre-specified quality and cost.
Specialist in tools such as WinNonLin/Phoenix NLME, NonMem,
Berkeley Madonna, MATLAB, and SimCYP.
Excellent interpersonal and communication skills.
Strong influence and leadership skills.
Experience in providing modelling support for other modalities
in addition to small molecules is a plus.
About The Site
The Waltham R&D site is home to our small-molecule oncology
research in North America, and is situated within a biopharma
cluster of academic research institutions, medical centers,
pharmaceutical companies and biotech startups. The Boston region is
consistently ranked #1 globally for biotech research, investment,
talent recruitment and lab space.
The campus, also known as the Boston BioHub, is one of the
largest and most dynamic life-science research hubs in the region.
It is home to more than 800 scientists and experts working in nine
different pharmaceutical and biotech companies. The site is also
home to the AstraZeneca Incubator, a program that helps emerging
companies advance novel and innovative healthcare solutions to meet
the needs of patients. Plenty of free parking, with charging
stations now available for electric vehicles, and shuttle service
to local transportation hubs.
Next Steps Apply today!
To be considered for this exciting opportunity, please complete
the full application on our website at your earliest convenience it
is the only way that our Recruiter and Hiring Manager can know that
you feel well qualified for this opportunity. If you know someone
who would be a great fit, please share this posting with them.